Cytomegalovirus (CMV) establishes lifelong infections with episodes of active replication. We hypothesized that recurrent CMV replication in older individuals may suppress protective immune responses to non-tuberculous mycobacteria (NTM) and so potentiate pulmonary disease. Accordingly, levels of antibodies to three CMV antigen preparations were higher in NTM patients than in age-matched controls. This did not reflect broad-spectrum B cell activation as total immunoglobulin levels were not equivalently increased.
CITATION STYLE
Amran, F. S., Kim, K., Lim, A., Thomson, R., Lee, S., Waterer, G., & Price, P. (2016, February 1). Is Pulmonary non-Tuberculous Mycobacterial Disease Linked with a High Burden of Latent Cytomegalovirus? Journal of Clinical Immunology. Springer New York LLC. https://doi.org/10.1007/s10875-016-0233-1
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