Correlation between HbA1c Levels with Several Methods of estimated Glomerular Filtration Rate Calculation : Study in type-2 diabetes mellitus patients

Abstract

ABSTRACTBackground: Diabetes Mellitus is a long-term chronic disease characterized by blood glucose levels enhancement (hyperglycemia). Diabetes is closely related to hyperglycemia conditions. Prolonged hyperglycemic conditions can initiate abnormal interactions of metabolic and hemodynamic factors and stimulate the establishment of fibronectin and collagen, including affecting eGFR values. This study analyzed the correlation between HbA1c level and several methods of calculating eGFR in patients with type-2 diabetes mellitus.Objective: Analyzing the correlation between HbA1c levels and several methods of calculating eGFR (CKD-EPI, MDRD, and CG) in patients with type-2 diabetes mellitus.Method: This study was a cross-sectional observational study on 85 research subjects aged over 18 in February to November 2021. The data were taken from medical records of type-2 diabetes mellitus patients at RSND Semarang. The statistical analysis used the Pearson test.Results: The Pearson results showed that there was a significant correlation between HbA1c levels and several methods of calculating eGFR in patients with type-2 diabetes mellitus (p=0,000; r=0,430 in the CKD-EPI method, p=0,000; r=0,384 in the MDRD method, p=0,001; r=0,361 in the CG method).Conclusion: There was a significant positive correlation between HbA1c levels and eGFR CG, MDRD, and CKD-EPI methods in patients with type-2 diabetes mellitus, characterized by increased HbA1c levels and still high eGFR values.Keywords: Diabetes mellitus, HbA1c, eGFR, CKD-EPI, MDRD, CG