Plasma renin and angiotensinogen levels in pathological states associated with oedema

Abstract

Plasma renin and angiotensinogen levels were determined in several pathological conditions associated with oedema. Plasma renin concentration was significantly increased in patients with the nephrotic syndrome and generalized oedema. It was also raised in patients without oedema on salt restriction. In cirrhosis of the liver, a marked increase in plasma renin concentration was noted when ascites was present. In those without ascites, it was also raised significantly. In patients in congestive heart failure or suffering from proteinlosing enteropathy, increased plasma renin concen-tration was associated with generalized oedema. In acute and chronic renal diseases with hypertension, plasma renin levels were decreased. Angiotensinogen levels were decreased in the initial phase of the nephrotic syndrome and in cirrhosis of the liver with ascites. It was increased considerably during the diuretic phase of the nephrotic syndrome.