Nanoscale carnosine patches improve organ function

Abstract

Carnosine (β-alanyl-L-histidine) is a naturally occurring dipeptide present in brain, cardiac muscle, stomach, kidney, olfactory bulbs and in large quantities in skeletal muscle. As free-radical-induced damage to the cells is an important factor in causing aging and senile diseases, carnosine has the potential ability to prevent and treat diseases such as atherosclerosis, diabetes, Alzheimer's and senile cataract. Recent clinical research shows that carnosine has the ability to rejuvenate senescent cells and delay eyesight impairment and cataract, which are manifestations of the aging process. These results provide valuable data in favor of considering carnosine as a natural anti-aging substance. Bioelectrical impedance data indicative of cellular physiologic organ function (status), using an Electro Interstitial Scanning (EIS) system, were acquired from twenty volunteers:7 males and 13 females, 19-83 (mean 43) years, 118-185 (mean 150) lbs in weight, and 5'-6' (mean 5',5") ft in height. Cellular physiologic function testing was evaluated in 10 organs (pancreas, liver, left/right kidneys, intestines, left /right adrenal glands, hypothalamus, pituitary and thyroid glands) while wearing a nanosclae carnosine patch for 2 weeks. EIS testing was repeated each week. Cellular physiologic function baseline data were acquired from all subjects at the beginning of the study period before application of the nanoscale carnosine patch. Subjects were instructed to keep well hydrated during the study period. All subjects served as their own control. The hypothesis to be tested was: The carnosine patch worn 12 hours/day on alternate days for two weeks significantly improves cellular physiologic functional status in different organs. Statistical analyses revealed that the carnosine patch worn 12 hours daily on alternate days (Tuesdays, Thursdays, and Saturdays) over a period of 2 weeks produced a very significant (p < 0.01) improvement in the physiologic functional status of the pancreas, liver, right kidney, left /right adrenals, hypothalamus, pituitary and thyroid glands with an average statistical power >95% © 2010 Springer-Verlag.