Objective: To explore the efficacy of primary chemoradiation with cisplatin versus cetuximab with respect to HPV/p16 and smoking statuses. Methods: We retrospectively reviewed patients from our center with locally advanced non-nasopharyngeal head and neck squamous cell carcinoma (HNSCC) who received primary chemoradiation with cisplatin or cetuximab between 2006 and 2018. Results: The median OS for cisplatin (n = 66) was not reached versus 132 months when treated with cetuximab (n = 55) (p = 0.03). For HPV/p16-positive patients, we found the median OS for cisplatin (n = 34) was not reached versus 60 months with cetuximab (n = 21) (p = 0.036). In the smoking group, the median OS was not reached in the cisplatin group (n = 44) versus 60 months when treated with cetuximab (n = 32) (p = 0.03). Conclusion: HPV/p16-positive and smoking cohorts treated with cisplatin-based chemoradiotherapy had a significantly better OS versus cetuximab.
CITATION STYLE
Jeong, I. S. D., Mo, H., Nguyen, A., Chong, E. G., Tsai, H. H. C., Moyers, J., … Cao, H. (2020). Primary chemoradiation with cisplatin versus cetuximab for locally advanced head and neck cancer: A retrospective cohort study. Experimental Hematology and Oncology, 9(1). https://doi.org/10.1186/s40164-020-00175-1
Mendeley helps you to discover research relevant for your work.