Trace element iron affects T cell biology, but the knowledge about the role of iron in regulating Treg cell expansion is limited. Treg cells play an important role in keeping peripheral T cell tolerance, increasing Treg cell expansion is a promising therapeutic method for SLE. Here we showed that iron deficiency promotes Treg cell expansion by reducing ROS accumulation, improving the disease progression of pristane-induced lupus. Increased oxidative stress inhibits Treg cell differentiation by inducing cell apoptosis. Our data suggest that altering iron metabolism promotes Treg cell expansion by preventing oxidation-induced cell death, which may provide a potential therapeutic strategy for SLE.
CITATION STYLE
Gao, X., Song, Y., Lu, S., Hu, L., Zheng, M., Jia, S., & Zhao, M. (2022). Insufficient Iron Improves Pristane-Induced Lupus by Promoting Treg Cell Expansion. Frontiers in Immunology, 13. https://doi.org/10.3389/fimmu.2022.799331
Mendeley helps you to discover research relevant for your work.