Triazole Antifungals: IV: Synthesis and Antifungal Activities of 3-Acylamino-2-aryl-2-butanol Derivatives

Abstract

New triazole compounds were designed and synthesized as potential inhibitors of the fungal cytochrome P-450 14a-demethylase. In testing for antifungal activity against a mouse systemic Candida albicans infection, (2/?,3/?)-3-acylamino-2-aryl-2-butanol derivatives III exhibited remarkably high efficacy after oral or parenteral administration. The structure-activity relationships of these amidoalcohols were evaluated. © 1991, The Pharmaceutical Society of Japan. All rights reserved.