Efficacy of fixed-dosing aflibercept for treating polypoidal choroidal vasculopathy: 1-year results of the VAULT study

42Citations
Citations of this article
42Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Purpose: To investigate fixed-dosing aflibercept for treating polypoidal choroidal vasculopathy (PCV). Methods: This phase IV, prospective, single-arm, interventional case series was conducted in eight centers. Forty treatment-naïve PCV patients were administered three monthly doses of intravitreal aflibercept (2.0 mg) and an injection every 2 months thereafter. Best-corrected visual acuity (BCVA) and central subfield macular thickness (CSMT) were measured at each visit. Fluorescein and indocyanine green angiography (ICGA) were performed at baseline, 3 and 12 months. The primary outcome measure was the proportion of patients who maintained BCVA (<15 letters loss) at 12 months. Changes in BCVA, macular appearance, and polypoidal lesion appearance were also examined. Results: Thirty-five eyes (87.5 %) had maintained BCVA at 12 months. Average BCVA was significantly higher at 12 months (20/53, 64.2 letters) than at baseline (20/80, 55.1 letters, 9-letter gain; P

References Powered by Scopus

5264Citations
902Readers
3269Citations
787Readers
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Lee, J. E., Shin, J. P., Kim, H. W., Chang, W., Kim, Y. C., Lee, S. J., … Lee, J. E. (2017). Efficacy of fixed-dosing aflibercept for treating polypoidal choroidal vasculopathy: 1-year results of the VAULT study. Graefe’s Archive for Clinical and Experimental Ophthalmology, 255(3), 493–502. https://doi.org/10.1007/s00417-016-3489-5

Readers over time

‘16‘17‘18‘19‘20‘21‘22‘23‘24‘2505101520

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 14

64%

Professor / Associate Prof. 4

18%

Researcher 4

18%

Readers' Discipline

Tooltip

Medicine and Dentistry 17

65%

Nursing and Health Professions 4

15%

Biochemistry, Genetics and Molecular Bi... 3

12%

Pharmacology, Toxicology and Pharmaceut... 2

8%

Save time finding and organizing research with Mendeley

Sign up for free
0