Copper-catalyzed trifluoromethylation of alkenes with an electrophilic trifluoromethylating reagent

Abstract

An efficient method for the copper-catalyzed trifluoromethylation of terminal alkenes with an electrophilic trifluoromethylating reagent has been developed. The reactions proceeded smoothly to give trifluoromethylated alkenes in good to excellent yields. The results provided a versatile approach for the construction of Cvinyl-CF3 bonds without using prefunctionalized substrates. © 2013 Wang et al.