Genomic Applications for Pediatric Orbital Tumours

Abstract

This chapter will highlight the genomic and epigenetic basis of paediatric orbital tumours, focusing on some of the more common lesions. It will attempt to illustrate the potential for targeted and individualized therapies which are now beginning to accompany the rapid advances in laboratory research. It is now apparent that as a more complete understanding of the genetic and epigenetic aberrations, cancer pathways and proteomics develops, a parallel improvement in available targeted therapies will become a practical reality in the management of these orbital cancers.