Assembly of the cell surface IL-10 receptor complex is the first step in initiating IL-10 signaling pathways that regulate intestinal inflammation, viral persistence and even tumor surveillance. The discovery of IL-10 homologs in the genomes of herpes viruses suggests IL-10 signaling pathways can be manipulated at the level of the receptor complex. This chapter will describe our current molecular understanding of IL-10 receptor assembly based on crystal structures and biochemical analyses of cellular and viral IL-10 receptor complexes. © 2014 Springer-Verlag Berlin Heidelberg.
CITATION STYLE
Walter, M. R. (2014). The molecular basis of IL-10 function: From receptor structure to the onset of signaling. Current Topics in Microbiology and Immunology. Springer Verlag. https://doi.org/10.1007/978-3-662-43492-5_9
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