Glucagon-like peptide-1 (GLP-1) is the main member of the incretin family and stimulates insulin secretion by binding with its specific receptor on pancreatic β-cells. In addition, GLP-1 exerts broad beneficial effects on the glucose regulation by suppressing food intake and delaying stomach emptying. Now, long acting GLP-1 analogs including exenatide and liraglutide have been approved for the treatment of diabetes mellitus type 2, however long-term injection can limit their use for these chronic patients. In this report, the authors provide a review on the development of non-peptide GLP-1 receptor agonists and introduce a novel agonist DA-15864. © 2011 The Pharmaceutical Society of Korea and Springer Netherlands.
CITATION STYLE
Moon, H. S., Kim, M. K., & Son, M. H. (2011, July). The development of non-peptide glucagon-like peptide-1 receptor agonist for the treatment of type 2 diabetes. Archives of Pharmacal Research. https://doi.org/10.1007/s12272-011-0721-z
Mendeley helps you to discover research relevant for your work.