Evaluation of the effects of gabapentin on the physiologic and echocardiographic variables of healthy cats: a prospective, randomized and blinded study

7Citations
Citations of this article
56Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Objectives: The aim of this study was to evaluate, using echocardiography, the effects of oral administration of a single dose of gabapentin on the physiologic variables (heart rate [HR], respiratory rate [RR] and systolic blood pressure [SBP]) and systolic and diastolic cardiac function of healthy cats. Methods: This was a prospective, randomized and blinded study with 40 healthy cats aged between 6 months and 2 years. The cats’ health status was assessed on the first appointment (T1) when they underwent a physical examination, complete blood count, biochemical profile, assessment of physiologic variables and echocardiogram. The echocardiogram was used to measure the left ventricle’s (LV) internal diameter during systole and diastole, isovolumic relaxation time, transmitral flow, E-wave deceleration time and HR. The cats were randomly divided into two groups: (1) a treatment group with 20 cats that received a single oral dose of gabapentin (100 mg/cat); and (2) a control group with 20 cats that received a single oral dose of placebo. All variables of the physiologic and echocardiographic variables were re-evaluated 1–3 weeks after T1 (T2), 90 mins after medication or placebo administration. Results: There was no difference in the physiologic variables evaluated in both groups. The proportion of cats in the treatment group that had their ventricular filling waves fused on T1 but did not have them fused on T2 was significantly higher (45%) compared with cats in the control group (15%; P = 0.0384). Conclusions and relevance: There was no difference between the groups in regard to SBP, HR, RR and echocardiographic variables. Gabapentin improved evaluation of diastolic function on echocardiogram because it reduced the fusion of ventricular filling waves during the evaluation of the diastolic function of the LV. Gabapentin did not cause adverse effects on the cardiovascular hemodynamics of young healthy cats.

References Powered by Scopus

Assessment of Diastolic Function of the Heart: Background and Current Applications of Doppler Echocardiography. Part II. Clinical Studies

681Citations
N/AReaders
Get full text

Mechanisms of the antinociceptive action of gabapentin

220Citations
N/AReaders
Get full text

AAFP and ISFM Feline-Friendly Handling Guidelines

156Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Effects of Acute and Chronic Gabapentin Treatment on Cardiovascular Function of Rats

3Citations
N/AReaders
Get full text

Effect of gabapentin on ambulatory, direct, systemic arterial blood pressure in apparently healthy cats in the at-home and in-clinic environments

3Citations
N/AReaders
Get full text

Assessment of the effect of gabapentin on blood pressure in cats with and without chronic kidney disease

1Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Veronezi, T. M., Lopes, D. J., Zardo, I. L., Ferronatto, J. V. B., Trojan, M. M., Franck, K. R., … da Costa, F. V. A. (2022). Evaluation of the effects of gabapentin on the physiologic and echocardiographic variables of healthy cats: a prospective, randomized and blinded study. Journal of Feline Medicine and Surgery, 24(12), e498–e504. https://doi.org/10.1177/1098612X221131270

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 9

56%

Professor / Associate Prof. 4

25%

Researcher 3

19%

Readers' Discipline

Tooltip

Veterinary Science and Veterinary Medic... 20

71%

Medicine and Dentistry 6

21%

Agricultural and Biological Sciences 1

4%

Biochemistry, Genetics and Molecular Bi... 1

4%

Save time finding and organizing research with Mendeley

Sign up for free