We propose an innovative machine learning paradigm enabling precision medicine for AD biomarker discovery. The paradigm tailors the imaging biomarker discovery process to individual characteristics of a given patient. We implement this paradigm using a newly developed learning-to-rank method (Forumala Presented). The (Forumala Presented). model seamlessly integrates two objectives for joint optimization: pushing up relevant biomarkers and ranking among relevant biomarkers. The empirical study of (Forumala Presented). conducted on the ADNI data yields promising results to identify and prioritize individual-specific amyloid imaging biomarkers based on the individual’s structural MRI data. The resulting top ranked imaging biomarker has the potential to aid personalized diagnosis and disease subtyping.
CITATION STYLE
Peng, B., Ren, Z., Yao, X., Liu, K., Saykin, A. J., Shen, L., & Ning, X. (2019). Prioritizing Amyloid Imaging Biomarkers in Alzheimer’s Disease via Learning to Rank. In Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) (Vol. 11846 LNCS, pp. 139–148). Springer. https://doi.org/10.1007/978-3-030-33226-6_16
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