Abstract
Deubiquitinating enzymes (DUBs) are a novel "drug-able" target for cervical cancer, and small-molecule inhibitors of DUBs are currently being evaluated as novel chemotherapeutic agents. In this chapter, we describe an enzyme activity assay to assess the selectivity of a putative small-molecule DUB inhibitor toward a subset of DUBs in cancer cell lines.
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Rivard, C., & Bazzaro, M. (2014). Measurement of deubiquitinating enzyme activity via a suicidal HA-Ub-VS probe. In Cervical Cancer: Methods and Protocols (pp. 193–200). Springer New York. https://doi.org/10.1007/978-1-4939-2013-6_14
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