Using novel In Vitro NociOcular assay based on TRPV1 channel activation for prediction of eye sting potential of baby shampoos

Abstract

Editor's Highlight: Replacing animal testing for pain induction by chemicals is a goal of animal welfare research. Forsby et al. make a significant advancement in this field by the development of the NociOccular test for baby bath and shampoo formulations. This assay is a recombinate neuronal in vitro model of activation of the Transient Receptor Potential Vanilloid type 1 channel, a well characterized pain-inducing receptor. This research opens the way for the development of future assays to predict pain induction without the use of animals. © The Author 2012. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved.