The clinical manifestations of Plasmodium falciparum malaria are directly linked to the blood stage of the parasite life cycle. At the blood stage, the circulating merozoites invade erythrocytes via a specific invasion pathway often identified with its dependence or independence on sialic acid residues of the host receptor. The invasion process involves multiple receptor-ligand interactions that mediate a complex series of events in a period of approximately 1 min. Although the mechanism by which merozoites invade erythrocytes is not fully understood, recent advances have put a new perspective on the importance of developing a multivalent blood stage-malaria vaccine. In this review, we highlight the role of currently identified host invasion receptors in blood-stage malaria. © Springer-Verlag Berlin Heidelberg 2005.
CITATION STYLE
Oh, S. S., & Chishti, A. H. (2005). Host receptors in malaria merozoite invasion. Current Topics in Microbiology and Immunology. Springer Verlag. https://doi.org/10.1007/3-540-29088-5_8
Mendeley helps you to discover research relevant for your work.