An enantioselective photooxidative Mannich reaction of dihydroquinoxalinones with ketones by the merger of organophotoredox and asymmetric organocatalysis is described. This protocol features very mild reaction conditions using simple and cheap catalysts (Eosin Y and (S)-Proline) for the synthesis of chiral quinoxaline derivatives with good to high yields (up to 94%) and excellent enantioselectivities (up to 99% ee). ©
CITATION STYLE
Rostoll-Berenguer, J., Blay, G., Muñoz, M. C., Pedro, J. R., & Vila, C. (2019). A Combination of Visible-Light Organophotoredox Catalysis and Asymmetric Organocatalysis for the Enantioselective Mannich Reaction of Dihydroquinoxalinones with Ketones. Organic Letters, 21(15), 6011–6015. https://doi.org/10.1021/acs.orglett.9b02157
Mendeley helps you to discover research relevant for your work.