Protein arrays, an excellent tool in biomedical research

Abstract

Although excellent progress has been made in simultaneous analysis of the whole genome, great challenge remains in the highly paralleled analysis of proteome. The development of protein arrays represents a major technology advance in the proteomics field. Advances in protein array technology include chemical surfaces, capture reagents, detection methods and arraying devices. Protein arrays can be classified into different groups. Potential applications of protein arrays include: 1) measurement of protein expression; 2) identification of interactions between protein-protein, protein-DNA and protein-small molecule; 3) analysis of protein modifications; and 4) determination of antibodies. Such protein array technology holds great promise in biomedical research and clinical applications.