Human brain structural organization in healthy volunteers and patients with schizophrenia

Abstract

The purpose of this work was to study and to compare the structural features of the human brain in two groups of people: healthy volunteers and patients with schizophrenia. According to the data of diffusion magnetic resonance imaging (dMRT), tractography pathways that describe the direction of fibers growth of the white matter of the human brain were reconstructed. Analysis of these paths made it possible to construct maps of the connectivity of all sections of the prepared brain to each other for each subject. With the help of graph theory, so-called rich-club areas were found for each of two groups, that, according to many papers, are the key centers of the brain in the transmission and exchange of information between all areas of the human brain.