In-feed macrolide Leucomycin (Leucomag 30% PR) for prevention of proliferative enteropathy in experimentally infected pigs

1Citations
Citations of this article
7Readers
Mendeley users who have this article in their library.

Abstract

The aim of this study was to evaluate the efficacy of orally administered leucomycin at 90 and 180ppm for the prevention of porcine proliferative enteropathy (PPE) in experimentally infected pigs. A total of 90 commercial fiveweek-old pigs were randomly assigned to receive leucomycin in feeding at 90 (T2), 180ppm (T3), or untreated (T1). All animals in the treated groups received medicated feed for 14 days starting one day before inoculation. Each pig was inoculated intragastrically with approximately 4.5×109 Lawsonia intracellularis in the form of porcine intestinal mucosal homogenate. Body weight, feed consumption and clinic signs were evaluated throughout the study. Necropsies and gross evaluation of intestines were performed in all animals on day 23 post-inoculation (pi) or at death, and ileum samples were collected for immunohistochemistry (IHC) for L. intracellularis. Clinical presentation of the disease was more evident in the non-medicated group (T1) than in the medicated ones (T2, T3) between days 16 and 21pi. Average daily gain, average daily feed consumption and feed conversion efficiency were better in groups treated with either dose of leucomycin. The total intestine lesion length per group (T1, T2 and T3) was 869, 473 and 331cm, respectively. The majority of the animals (84.4%) were positive for L. intracellularis antigen in ileum sections stained by IHC. Under the conditions of this study, leucomycin administered in feed at 90 and 180ppm for 14 days was effective in improving performance of pigs inoculated with intestinal homogenate containing L. intracellularis.

Cite

CITATION STYLE

APA

França, S. de A., Machado, G. de S., Andreoli, P. R., Santos, J. C. B., & Guedes, R. M. C. (2010). In-feed macrolide Leucomycin (Leucomag 30% PR) for prevention of proliferative enteropathy in experimentally infected pigs. Ciencia Rural, 40(6), 1378–1384. https://doi.org/10.1590/s0103-84782010005000101

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free