Microwave synthesis and antimicrobial activity of some copper (II), cobalt (II), nickel (II) and chromium (III) complexes with schiff base 2,6-pyridinedicarboxaldehyde-thiosemicarbazone

Abstract

Some novel Schiff base metal complexes of Cr(III), Co(II), Ni(II) and Cu(II) derived from 2, 6-pyridinedicarboxaldehyde-Thiosemicarbazone (PDCTC) was synthesized by conventional as well as microwave methods. This compound was characterized by elemental analysis, FT-IR, Mass, molar conductance and magnetic susceptibility measurements analyses. Analytical data revealed that all the complexes exhibited 1:1 (metal: ligand) ratio with a coordination number of six. The IR data showed that the ligand coordinates with the metal ions in ahexa-dentate manner. The solid state electrical conductivity of the metal complexes was also measured. Solid state electrical conductivity studies reflected a semi-conducting nature of the complexes. The Schiff base and metal complexes displayed good activity against the Gram-positive bacteria Staphylococcus aureus, the Gram-negative bacteria Escherichia coli and the fungi Aspergillusniger and Candida albicans. The antimicrobial results also indicated that the metal complexes displayed better antimicrobial activity as compared to the Schiff bases.