Ameliorative effects of the ethanolic extract of Allium saralicum R.M. Fritsch on CCl 4 -induced nephrotoxicity in mice: A stereological examination

83Citations
Citations of this article
20Readers
Mendeley users who have this article in their library.

Abstract

The present study was carried out to investigate the nephroprotective effect of the ethanolic extract of Allium saralicum R.M. Fritsch (ASRMF) in mice. Thirty-five male mice were divided into five groups (n=7). Group 1 (positive control) received 1 mL/kg olive oil intraperitoneally (i.p.) and 0.5 mL distilled water orally; Group 2 (negative control) received CCl 4 (50% in olive oil, 1 mg/kg; i.p.); Groups 3, 4 and 5 received CCl 4 and 200, 800 and 1600 μg/kg of ASRMF extract, respectively. The renal volume and cortex in Groups 1 and 2 were increased by 55% and 62% (p≤0.001) following CCl 4 administration, respectively, and were improved after ASRMF administration. The volume of proximal convoluted tubules (PCTs), glomeruli, vessels and interstitial tissue increased 80%, 150%, 83% and 64% (p≤0.05), respectively, in CCl 4 - treated mice, and decreased significantly with 800 and 1600 μg/kg of ASRMF. The length of PCTs and vessels increased 51% and 45% and decreased (p≤0.05) with 200, 800 and 1600 μg/kg of ASRMF, respectively. CCl 4 -treated mice lost 22.5% of glomeruli; the loss was inhibited significantly (p≤0.05) by ASRMF. Urea and creatinine concentrations were increased (p≤0.05) in CCl 4 -induced nephrotoxicity as compared to the controls, whereas different doses of ASRMF restored the levels of these biomarkers compared to the negative controls. In conclusion, ASRMF has a potent nephroprotective property and can improve renal structural and serum biomarkers in CCl 4 -induced nephrotoxicity in mice.

Cite

CITATION STYLE

APA

Sherkatolabbasieh, H., Hagh-Nazari, L., Shafiezadeh, S., Goodarzi, N., Zangeneh, M. M., & Zangeneh, A. (2017). Ameliorative effects of the ethanolic extract of Allium saralicum R.M. Fritsch on CCl 4 -induced nephrotoxicity in mice: A stereological examination. Archives of Biological Sciences, 69(3), 535–543. https://doi.org/10.2298/ABS160914129S

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free