B lymphocyte maturation-induced protein-1 (Blimp1) is a transcrip-tional repressor expressed in diverse cell types. In the adaptive immune system, Blimp1 is expressed in lymphocytes that have undergone effector differentiation. Blimp1 is a master regulator of plasma cell differentiation and plays important roles in controlling T cell homeostasis and effector differentiation. Blimp1 can be induced by a variety of cytokines including IL-2, IL-4, IL-12, and IL-21 in addition to TCR and co-stimulatory signals. Blimp1-deficient mice develop spontaneous inflammatory disease mediated by infiltration of activated T cells into tissues. During immune responses Blimp1 is required for the differentiation of plasma cells as well as short-lived CD8+ cytotoxic T cells. Mounting evidence suggests that Blimp1 plays a common role in the terminal differentiation of multiple cell subsets. © 2011 Springer Science+Businees Media, LLC.
CITATION STYLE
Xin, A., Nutt, S. L., Belz, G. T., & Kallies, A. (2011). Blimp1: Driving terminal differentiation to a T. In Advances in Experimental Medicine and Biology (Vol. 780, pp. 85–100). https://doi.org/10.1007/978-1-4419-5632-3_8
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