Age-related macular degeneration is a complex genetic disorder. Recent data suggest that the additive genetic risk for late-stage disease is more than two-thirds. Comprehensive genetic studies (candidate gene approaches, linkage and association studies) have been performed in recent years to identity the genetic risk factors at the molecular lavel. Very recently, a significant risk allele, Y402H, has been discovered in the complement factor H (CFH) gene. The relative risk of developing AMD has been estimated between 2.4-4.6 for heterozygotes and 3.3-7.4 for homozygotes. This polymorphism accounts for approximately 20-50% of the overall risk of developing AMD. In this review the results from molecular genetic studies in AMD are summarized, with a special emphasis on the recent data obtained for the CFH gene. © Springer Medizin Verlag 2005.
CITATION STYLE
Scholl, H. P. N., Weber, B. H. F., Nöthen, M. M., Wienker, T., & Holz, F. G. (2005). Y402H polymorphism in complement factor H and age-related macula degeneration (AMD). Ophthalmologe, 102(11), 1029–1035. https://doi.org/10.1007/s00347-005-1270-y
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