The measurement of avian cellular immunity is critical to understanding the role and regulation of avian lymphocytes following avian influenza (AI) virus infection. Although the ability to measure avian T cell responses has steadily increased over the last few years, few studies have examined the role of cell-mediated immunity in avian species against the AI virus. Because of the structural and functional differences between mammalian and avian immune systems-including MHC architecture, different modes of somatic recombination for antibody production, and the absence of lymph nodes in birds-the extent to which birds and mammals regulate similar immune responses against the AI virus is currently under investigation. The increasing availability of monoclonal antibodies recognizing avian T cell-associated antigens as well as a number of inbred lines of chickens with genetically defined MHC haplotypes make this an important field of research for the future. © 2008 Humana Press.
CITATION STYLE
Kapczynski, D. R. (2008). Evaluating the cell-mediated immune response of avian species to avian influenza viruses. Methods in Molecular Biology, 436, 113–126. https://doi.org/10.1007/978-1-59745-279-3_13
Mendeley helps you to discover research relevant for your work.