Primary sclerosing cholangitis (PSC) is closely associated with inflammatory bowel disease (IBD). Although there is a clear genetic association between PSC and IBD, the underlying pathogenesis linking these diseases remains unclear. Many studies describe PSC-associated IBD (PSC-IBD) as a distinct phenotype characterized by extensive colitis with predominantly right colon inflammation and rectal sparing as well as a dramatically increased risk of colorectal cancer (CRC). The prevention and management of unfavorable outcomes related to colonic dysplasia are key aspects to the care of patients with PSC.-IBD. Additional challenges are posed by the management of IBD in the setting of liver transplantation. In summary, PSC-IBD is a common occurrence among PSC patients that presents distinct diagnostic, prognostic, and management issues with additional unique considerations in the posttransplant setting.
CITATION STYLE
Fennimore, B., Regner, E. H., & Gerich, M. E. (2016). Primary sclerosing cholangitis-associated inflammatory bowel disease. In Primary Sclerosing Cholangitis: Current Understanding, Management, and Future Developments (pp. 29–40). Springer International Publishing. https://doi.org/10.1007/978-3-319-40908-5_3
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