Both high and low levels of cellular Epstein-Barr virus DNA in blood identify failure after hematologic stem cell transplantation in conjunction with acute GVHD and type of conditioning

12Citations
Citations of this article
26Readers
Mendeley users who have this article in their library.

Abstract

The level of Epstein-Barr virus DNA in blood has proven to be a biomarker with some predictive value in allogeneic hematopoietic stem cell transplantation patients (HSCT). We evaluated the impact of EBV load on survival of 51 patients (32M/19F, median age: 32 years, from < 1 to 68 years old), who had received HSCT for different types of malignancies (49 cases) or non-malignancies (2 cases). The overall survival [1]was compared between patients with extreme and moderate cell bound EBV DNA levels. Different sources of stem-cells (peripheral blood stem, n = 39; bone marrow, n = 9; or umbilical cord blood, n = 3) were used. Twenty patients received reducedintensity conditioning regimen while the other 31 received myeloablative conditioning. Patients with high or very low level of cell bound EBV-DNA levels had a shorter OS than those with moderate EBV load: OS at 5 years was 67% vs 90% (p < 0.03). There was a conspicuous relationship between EBV load and the reconstitution dynamics of total and EBV-specific T cells, CD4+ and CD4- CD8- (double negative) T cells in the few patients where it was analyzed. This was not statistically significant. Two other factors were associated to early mortality in addition to high or low EBV load: Acute GVHD II-IV (p < 0.02) and pre-transplant conditioning with total body irradiation (TBI) ≥ 6 Gy, (p < 0.03). All the patients meeting all three criteria died within two years after transplantation. This points to a subgroup of HSCT patients which deserve special attention with improvement of future, personalized treatment.

References Powered by Scopus

DNA sequence and expression of the B95-8 Epstein - Barr virus genome

1650Citations
N/AReaders
Get full text

Quantitative analysis of Epstein-Barr virus load by using a real-time PCR assay

502Citations
N/AReaders
Get full text

Epstein–barr virus, immunodeficiency, and b cell lymphoproliferation

398Citations
N/AReaders
Get full text

Cited by Powered by Scopus

A Dynamic Model of Immune Responses to Antigen Presentation Predicts Different Regions of Tumor or Pathogen Elimination

42Citations
N/AReaders
Get full text

Viral Infections in HSCT: Detection, Monitoring, Clinical Management, and Immunologic Implications

40Citations
N/AReaders
Get full text

Epstein–Barr virus reactivation after allogeneic hematopoietic stem cell transplantation: multifactorial impact on transplant outcomes

30Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Li, Q., Rane, L., Poiret, T., Zou, J., Magalhaes, I., Ahmed, R., … Ernberg, I. (2016). Both high and low levels of cellular Epstein-Barr virus DNA in blood identify failure after hematologic stem cell transplantation in conjunction with acute GVHD and type of conditioning. Oncotarget, 7(21), 30230–30240. https://doi.org/10.18632/oncotarget.8803

Readers over time

‘16‘17‘18‘19‘20‘21‘23‘24036912

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 7

47%

Professor / Associate Prof. 4

27%

Researcher 3

20%

Lecturer / Post doc 1

7%

Readers' Discipline

Tooltip

Medicine and Dentistry 8

53%

Immunology and Microbiology 4

27%

Agricultural and Biological Sciences 2

13%

Pharmacology, Toxicology and Pharmaceut... 1

7%

Save time finding and organizing research with Mendeley

Sign up for free
0