Granulomatosis with polyangiitis: Recurrence or treatment consequences?

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Abstract

Granulomatosis with polyangiitis (GPA) is the most common antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). We describe the case of a 38-year-old woman with relapsing GPA who presented with intracranial hypertension, followed by the appearance of cavitated lung nodules despite treatment with azathioprine. Clinical improvement and ANCA titre reduction were observed after rituximab treatment. We report a rare form of GPA relapse and highlight the challenge of following-up patients with GPA, in whom can be hard to distinguish relapse from the consequences of long-term immunosuppression.

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Diegues, A., Tavares, J., Sá, D., Oliveira, J., Fernandes, D., Santos, J., & Rocha, G. (2021). Granulomatosis with polyangiitis: Recurrence or treatment consequences? European Journal of Case Reports in Internal Medicine, 8(4). https://doi.org/10.12890/2021_002448

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