Formulation and characterization of amlodipine loaded in-situ film forming hydrogen for dermal drug delivery

Abstract

Present work involves the development of novel in situ film-forming hydrogels (FFH) consisting of primarily Carbopol 934P, HPMC E50 LV and PEG 400. Here, propylene glycol was employed as a permeation enhancer for studying its effect in the formation of FFH and drug permeation. Prepared formulations were assessed for various parameters. Prepared FFH was uniform in weight and thickness with acceptable pH, viscosity and spreadability. Prepared FFH was able to form the in- situ film on the skin surface within 7min. propylene glycol was found to have a direct relationship with moisture content, moisture uptake and water vapour transmission. Higher drug encapsulation and better permeation were also observed when concentration of propylene glycol was increased. All formulations were non-irritating to the skin and thus acceptable. In conclusion, prepared in-situ film-forming hydrogel can be effectively used as a novel dermal drug delivery system.