Example of sacrificial unit using two different click reactions in coupling and decoupling (CAD) chemistry

Abstract

An example of a specific coupling and decoupling (CAD) chemistry is described. It takes advantage of propargyl acrylate as a sacrificial unit (SU). The addition of a selected compound representing a molecular unit equipped with an azide functionality to the terminal triple bond of the SU and another compound acting as a molecular unit equipped with a thiol functionality to the conjugated double bond of the SU proceeded at very good yields. The construct containing two molecular units can be decoupled using a few different reactions and the decoupling can take place at two positions.