T cells are the main cellular targets of the human immunodeficiency virus 1 (HIV-1). HIV-1 infection induces pleiotropic effects on the infected T cell that modify the T cell capacity to respond to antigen and facilitates virus replication. HIV-1 infection subverts the formation and function of the immunological synapse altering both actin cytoskeleton remodeling and intracellular vesicle traffic. We describe here our methods to unveil how HIV-1 and in particular its protein Nef modify vesicle traffic to the immunological synapse, perturbing the synapse activation capacity.
CITATION STYLE
del Río-Iñiguez, I., Bouchet, J., & Alcover, A. (2017). Studying the immune synapse in HIV-1 infection. In Methods in Molecular Biology (Vol. 1584, pp. 545–557). Humana Press Inc. https://doi.org/10.1007/978-1-4939-6881-7_34
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