Space State Approach to Study the Effect of Sodium over Cytosolic Calcium Profile

Abstract

Calcium is known to play an important role in signal transduction, synaptic plasticity, gene expression, muscle contraction etc. A number of researchers have studied Cytosolic calcium diffusion but none have studied the effect of sodium over Cytosolic calcium profile. Here in this paper we have developed a mathematical model which incorporates all the important parameters like permeability coefficient, calcium flux, sodium flux, external sodium, external calcium etc. Thus we can study dynamically changing calcium with respect to dynamically changing sodium. Further, we have used Space State approach for the simulation of the proposed model which is a novel technique in itself developed in the later part of the twentieth century.