Automatic prognostic determination and evolution of cognitive decline using artificial neural networks

Abstract

This work tries to go a step further in the development of methods based on automatic learning techniques to parse and interpret data relating to cognitive decline (CD). There have been studied the neuropsychological tests of 267 consultations made over 30 patients by the Alzheimer's Patient Association of Gran Canaria in 2005. The Sanger neural network adaptation for missing values treatment has allowed making a Principal Components Analysis (PCA) on the successfully obtained data. The results show that the first three obtained principal components are able to extract information relating to functional, cognitive and instrumental sintomatology, respectively, from the test. By means of these techniques, it is possible to develop tools that allow physicians to quantify, view and make a better pursuit of the sintomatology associated to the cognitive decline processes, contributing to a better knowledge of these ones. © Springer-Verlag Berlin Heidelberg 2007.