The Relative Merits of Acute Phase Proteins in the Recognition of Inflammatory Conditions

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Abstract

A study has been undertaken on the relative merits of a variety of acute phase proteins in the assessment of patients with inflammatory conditions. Five acute phase proteins (α1-antitrypsin, α1-antichymotrypsin, orosomucoid, haptoglobin and C-reactive protein) and the ESR were measured in 171 patients presenting to the gastroenterologists (gastrointestinal disease: 130, other disease: 41). Assessment of the sensitivity and specificity of the proteins and the ESR showed α1-antichymotrypsin to be the most sensitive test (95%) with specificity (81%) similar to the other acute phase proteins measured. Factors such as oestrogens, renal failure and genetic variants affected the value of α1-antitrypsin, orosomucoid and haptoglobin. In the routine protein laboratory the combination of a ‘short’ half-life and ‘long’ half-life protein is likely to offer the most useful screen for inflammation in samples obtained from a wide range of patients. The two acute phase proteins C-reactive protein and α1-antichymotrypsin fulfil these criteria. © 1988, Association for Clinical Biochemistry. All rights reserved.

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Calvin, J., Neale, G., Fotherby, K. J., & Price, C. P. (1988). The Relative Merits of Acute Phase Proteins in the Recognition of Inflammatory Conditions. Annals of Clinical Biochemistry, 25(1), 60–66. https://doi.org/10.1177/000456328802500108

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