Abstract
1,6-Diynes with a t-butylcarbonate group in the propargylic position undergo gold(I)-catalyzed domino-cyclization which affords α-hydroxycyclohexenones. The described sequence can be applied on functionalized, highly oxygenated substrates, as examplified in the synthesis of (-)-gabosine H and its epimer.
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CITATION STYLE
APA
Vulovic, B., Kolarski, D., Bihelovic, F., Matovic, R., Gruden, M., & Saicic, R. N. (2016). Gold(I)-Catalyzed Domino Cyclizations of Diynes for the Synthesis of Functionalized Cyclohexenone Derivatives. Total Synthesis of (-)-Gabosine H and (-)-6-epi-Gabosine H. Organic Letters, 18(15), 3886–3889. https://doi.org/10.1021/acs.orglett.6b01898
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