Impact of magnification views on the characterization of microcalcifications in digital mammography

Abstract

Purpose: To evaluate the additional benefit of true geometric (air-gap) magnification views for the characterization of microcalcifications in digital mammography. Materials and Methods: After ethical approval, we retrospectively reviewed patient records to identify 100 patients with suspicious microcalcifications (35 malignant, 65 benign) who had a standard digital mammography and an additional digital magnification view in the same projection within three months. All images were obtained using an amorphous silicon-based full-field digital system (Senographe 2000D, GE Healthcare, Chalfont St. Giles, UK). Images were independently analyzed by six board-certified radiologists. The probability of malignancy was estimated using first standard contact mammography alone (MG) and then mammography in combination with the magnification view (MG+MAG) using a modified Breast Imaging Reporting and Data System (BI-RADS) classification system and a percentage scale. Results were compared using receiver operating characteristic (ROC) analysis. In addition, readers assessed the subjective visibility of the calcifications. Results: For all six readers combined, the area under the curve (AUC) was 0.664±0.052 for MG and 0.813±0.042 for MG+MAG, resulting in a statistically significant improvement of 0.148±0.120. Each reader had a higher AUC for MG+MAG than MG, with the improvement being statistically significant in four of the six readers. In 76.34% of the cases, MG+MAG resulted in better visibility of calcifications compared with mammography alone. In 33% slightly more and in 39% significantly more calcifications were found. Conclusion: Even in digital mammography with the option of using electronic magnification (zoom) at the viewing workstation, true geometric (air-gap) magnification views remain important for the visibility and correct classification of microcalcifications and for the assessment of their extent. Citation Format: Fallenberg EM, Dimitrijevic L, Diekmann F etal. Impact of Magnification Views on the Characterization of Microcalcifications in Digital Mammography. Fortschr Röntgenstr 2014; 186: 274-280.© Georg Thieme Verlag KG Stuttgart.