Anticancer effects of Annona muricata with its acetogenins as bioactive compound

Abstract

Annona muricata, commonly known as soursop, graviola and guanabana, is a member of the Annonaceae family and is mostly distributed in tropical and subtropical regions of the world. In the absence of an effective treatment in modern medicine, efforts are being made to find suitable herbal drugs. The use of natural product medicines has emerged from traditional to modern therapy in order to increase the quality of health worldwide. The soursop is a traditional medicinal plant which is empirically by the people of Indonesia is used for anti-inflammatory and anti-tumor. A wide array of ethnomedicinal activities is contributed to different parts of Annona muricata, and indigenous communities in Africa and South America extensively use this plant in their folk medicine. Soursop has anticancer, anticonvulsant, anti-arthritic, antiparasitic, antimalarial, hepatoprotective and antidiabetic activities. Phytochemical studies reveal that annonaceous acetogenins are the major constituents of A. muricata. A wide range of chemical compounds including Alkaloids (acetogenins), lipids, isoquinoline, lactones, Annomuricatina (protein), Bullatacin, Muricoreacin etc. have been isolated from this species. The annonaceous acetogenins are selectively toxic to cancer cells, including multi-drug-resistant cancer cell lines. So, the review work mainly focused on the anticancer activity of Annona muricata, here is the initiation for the future anticancer drug from the natural source.