Incidence of recurrent high-grade anal dysplasia in HIV-1-infected men and women following infrared coagulation ablation: A retrospective cohort study

1Citations
Citations of this article
13Readers
Mendeley users who have this article in their library.

Abstract

This single-center, retrospective cohort study sought to estimate the cumulative incidence in HIV-1-infected patients of biopsy-proven high-grade anal intraepithelial neoplasia (HGAIN) recurrence after infrared coagulation (IRC) treatment. The study was based on data from a prospectively compiled database of 665 HIV-1-infected outpatients who attended a hospital Clinical Proctology/HIV Unit between January 2012 and December 2015. Patient records were checked to see which ones had received IRC treatment but later experienced a recurrence of HGAIN. Cytology samples were also checked for the presence of human papilloma virus (HPV). A total of 81 of the 665 patients (12%, 95%CI: 10-15%), of whom 65 were men and 16 women, were diagnosed with HGAIN and again treated with IRC. Of these 81, 20 (25%) experienced recurrent HGAIN, this incidence being true of both men (16/65, 95%CI: 19-57%) and women (4/16, 95%CI: 10-50%). The median time to recurrence was 6 (2-19) months overall, 6 (2-19) months in men, and 4 (2-6) months in women. HPV infection was detected in all patients except two, with HPV-16 being the most common genotype. This rate of incidence of recurrent HGAIN following IRC treatment is consistent with other reports and highlights the importance of continued post-treatment surveillance, particularly in the first year.

Cite

CITATION STYLE

APA

Corral, J., Parés, D., García-Cuyás, F., Revollo, B., Chamorro, A., Lecumberri, C., … Sirera, G. (2021). Incidence of recurrent high-grade anal dysplasia in HIV-1-infected men and women following infrared coagulation ablation: A retrospective cohort study. Pathogens, 10(2), 1–7. https://doi.org/10.3390/pathogens10020208

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free