Microbiological asymmetric reduction of methyl 3-(2-furyl)-2-methyl-3-oxopropionate (5) by various yeasts was carried out. Four kinds of methyl 3-(2-furyl)-3-hydroxy-2-methyl propionates (6a—6d) could be obtained separately from the prochiral β-keto ester 5 by reduction with properly selected microorganisms. In particular, the desired syn-isomer 6a was obtained with high optical purity (>99% e.e.). Both the chemical yield and the optical purity of the reduction products (6a—6d) were significantly improved when fermentation was carried out on a large scale using a 30 1 jar fermentor or a 200 1 tank. © 1984, The Pharmaceutical Society of Japan. All rights reserved.
CITATION STYLE
Akita, H., Furuichi, A., Koshiji, H., Oishi, T., & Horikoshi, K. (1984). The Use of Microorganisms in Organic Synthesis. III. Microbiological Asymmetric Reduction of Methyl 3-(2-Furyl)-2-methyl-3-oxopropionate. Chemical and Pharmaceutical Bulletin, 32(4), 1333–1341. https://doi.org/10.1248/cpb.32.1333
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