Imaging in immunology research

Abstract

The immune system is central to health and tools to measure its dynamic function are critically needed in research and clinical settings. Molecular imaging modalities such as optical imaging, positron emission tomography (PET), computed tomography, and magnetic resonance imaging enable noninvasive longitudinal studies of immune function throughout the body. In vivo molecular imaging studies in small animals have revealed patterns of immune cell localization, trafficking, and function that cannot be obtained using conventional immune monitoring methods. This chapter reviews applications of optical imaging and PET in the study of immune trafficking and function, models of disease, and cancer immunotherapies with an assessment of the challenges facing the field. © 2011 Springer-Verlag Berlin Heidelberg.