Xenogenic cardiomyocytes transplantation for the treatment of curing acute myocardial infarction

Abstract

The autogenic cardiomyocytes transplantation presents numerous challenges in clinical application, such as the difficulty to obtain the autogenic cells, etc. Therefore, it is necessary to investigate allogenic or xenogenic cardiomyocytes transplantation. In this study, the experimental rabbits with acute infarcted myocardium were randomly divided into 3 groups: the 7-day cultured cardiomyocytes group, the 2-day cultured cardiomyocytes group and the control group. Neonate rat cardiomyocytes were labeled by DAPI and then injected into the acute infarcted myocardium of rabbits. After transplantation, results showed that, compared to the control group, the survival number of grafted cardiomyocytes in the cultured group is significantly larger (P < 0.05), with the implanted cardiomyocytes parallel to the host myocardium in an aligning direction. However, compared to the control group, the ventricular wall of the two experimental groups is thicker and the condition of myocardial fibrosis is better, especially to 7-day cultured cardiomyocytes group. These results suggested that the transplantation of xenogenic cardiomyocytes into curing acute ischemic heart of animal model is possible. © 2011 Versita Warsaw and Springer-Verlag Wien.