Whole-organ decellularization has opened the gates to the creation of 3D extracellular matrix (ECM) templates that mimic nature's design to a degree that - as for today - is not reproducible with any synthetic materials. Here, we describe a whole-heart decellularization approach through software-controlled automated coronary perfusion with standard decellularization detergents, enabling us to create native ECM-derived 3D templates that preserve the basic anatomy, vascular network, and critical ECM characteristics of the native heart. Such a cardiac ECM platform directly derived from nature itself might help us to better understand and reproduce cardiac biology and may even lay the grounds for the construction of a bioartificial heart in the future. © 2013 Springer Science+Business Media New York.
CITATION STYLE
Aubin, H., Kranz, A., Hülsmann, J., Lichtenberg, A., & Akhyari, P. (2013). Decellularized whole heart for bioartificial heart. Methods in Molecular Biology, 1036, 163–178. https://doi.org/10.1007/978-1-62703-511-8_14
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