PO-0321 Noninvasive Ventilation And Alveolar Recruitment Manoeuvre Improve Respiratory Function During Induction Of Anaesthesia Of Newborn With Higher Lever Intra-abdominal Pressure

Abstract

Background Morbid obesity predisposes patients to lung collapse and hypoxemia during induction of anaesthesia. The aim of this prospective study was to determine whether noninvasive positive pressure ventilation (NPPV) improves arterial oxygenation and end-expiratory lung volume (EELV) compared with conventional preoxygenation, and whether NPPV followed by early recruitment manoeuvre (RM) after endotracheal intubation (ETI) further improves oxygenation and respiratory function compared with NPPV alone. Methods 24 patients with higher lever intra-abdominal pressure (15,2 +/- 2,4 cm H 2 O) were randomised to receive 5 min of either conventional preoxygenation with spontaneous breathing of 100% O 2 (CON), NPPV (pressure support and positive end-expiratory pressure), or NPPV followed by RM (NPPV+RM). Gas exchange was measured in awake patients, at the end of preoxygenation, immediately after ETI, and 5 min after the onset of mechanical ventilation. EELV was measured immediately after ETI and 5 min after mechanical ventilation. The primary endpoint was arterial oxygenation 5 min after the onset of mechanical ventilation. Intra-abdominal pressure (IAP) was controlled by Cron Results are presented as mean +/- SD. Results At the end of preoxygenation, PaO 2 was higher in the NPPV and NPPV+RM groups (382 +/- 68 mmHg and 362 +/- 71 mmHg, respectively; both p < 0.001) compared with the CON group (297 +/- 49 mmHg) and remained higher after ETI (234 +/- 90 mmHg and 206 +/- 94 mmHg, in the NPPV and NPPV+RM groups, respectively; both p < 0.01 compared with the CON group [142 +/- 44 mmHg]). After the onset of mechanical ventilation, PaO 2 was90 +/- 28 mmHg in the CON group, 118 +/- 48 mmHg in the NPPV group (p = 0.035 vs. CON group), and 211 +/- 59 mmHg in the NPPV+RM group (p < 0.0001 vs. NPPV group). After ETI, EELV was higher in the NPPV group compared with the CON group (p < 0.001). Compared with NPPV alone, RM further improved gas exchange and EELV (all p < 0.05). A significant correlation was found between Pa O 2 obtained 5 min after mechanical ventilation and EELV (R = 0.41, p < 0.001). Conclusion NPPV improves oxygenation and EELV in children with higher lever intra-abdominal pressure compared with conventional preoxygenation. NPPV combined with early RM is more effective than NPPV alone at improving respiratory function after ETI.