Renal metabolism and hypertension

96Citations
Citations of this article
168Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Hypertension is a leading risk factor for disease burden worldwide. The kidneys, which have a high specific metabolic rate, play an essential role in the long-term regulation of arterial blood pressure. In this review, we discuss the emerging role of renal metabolism in the development of hypertension. Renal energy and substrate metabolism is characterized by several important and, in some cases, unique features. Recent advances suggest that alterations of renal metabolism may result from genetic abnormalities or serve initially as a physiological response to environmental stressors to support tubular transport, which may ultimately affect regulatory pathways and lead to unfavorable cellular and pathophysiological consequences that contribute to the development of hypertension.

Cite

CITATION STYLE

APA

Tian, Z., & Liang, M. (2021, December 1). Renal metabolism and hypertension. Nature Communications. Nature Research. https://doi.org/10.1038/s41467-021-21301-5

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free