GI Peptides, Energy Balance, and Cancer

Abstract

Beyond its role in nutrient absorption, the gastrointestinal tract is a vital endocrine organ responsible for the production of a variety of regulatory peptides that modulate energy balance. In this chapter, the most studied gastrointestinal peptides are described, with emphasis on their roles played in appetite control, glucose homeostasis, and weight disorders. Translational research investigating drug development targeting the ``gut-brain{''} axis regulatory pathway for the treatment of obesity and diabetes is also highlighted. Several GI peptides have proliferative and/or pro-apoptotic functions and their possible cancer-related effects are discussed.