Background: The immunohistochemical detection of Enhancer of zeste homologue 2 (EZH2) proved to be a useful tool to recognize the malignant nature of tumors in a wide variety of neoplasms. The histological diagnostics of salivary gland tumors is a challenging task, and a reliable marker of malignancy would be extremely helpful. Methods: EZH2 expression was investigated in 54 malignant and 40 benign salivary gland tumors of various histological types by standard immunohistochemistry. Results: The majority (n = 52) of the malignant tumors stained positively, while all the investigated benign tumors were negative for EZH2. Conclusions: EZH2 expression in salivary gland tumors, similarly to the tumors of other organs is not characteristic for any tumor type, but is a solid marker of the malignant nature of the tumors.
CITATION STYLE
Hajósi-Kalcakosz, S., Vincze, E., Dezso, K., Paku, S., Rókusz, A., Sápi, Z., … Nagy, P. (2015). EZH2 is a sensitive marker of malignancy in salivary gland tumors. Diagnostic Pathology, 10(1). https://doi.org/10.1186/s13000-015-0392-z
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