Predicted Vitamin D Status and Colorectal Cancer Incidence in the Black Women's Health Study

  • Barber L
  • Bertrand K
  • Petrick J
  • et al.
0Citations
Citations of this article
1Readers
Mendeley users who have this article in their library.
Get full text

Abstract

Background: Observational studies, mostly among White populations, suggest that low vitamin D levels increase colorectal cancer risk. African Americans, who are disproportionately burdened by colorectal cancer, often have lower vitamin D levels compared with other populations. Methods: We assessed predicted vitamin D score in relation to colorectal cancer among 49,534 participants in the Black Women’s Health Study, a cohort of African American women followed from 1995 to 2017 through biennial questionnaires. We derived predicted vitamin D scores at each questionnaire cycle for all participants using a previously validated prediction model based on actual 25-hydroxyvitamin D values from a subset of participants. We calculated cumulative average predicted vitamin D score at every cycle by averaging scores from cycles up to and including that cycle. Using Cox proportional hazards regression, we estimated hazard ratios (HR) and 95% confidence intervals (CI) for colorectal cancer incidence according to predicted score quartiles. Results: Over follow-up, 488 incident colorectal cancers occurred. Compared with women in the highest quartile of predicted vitamin D score, those in the lowest had an estimated 41% (HR ¼ 1.41; 95% CI, 1.05–1.90) higher colorectal cancer risk. Comparable HRs were 1.44 (95% CI, 1.02–2.01) for colon and 1.34 (95% CI, 0.70–2.56) for rectal cancer. Conclusions: Low vitamin D status may lead to elevated colorectal cancer risk in African American women. Impact: Our findings, taken together with established evidence that vitamin D levels are generally lower in African Americans than other U.S. groups, suggest that low vitamin D status may contribute to the disproportionately high colorectal cancer incidence among African Americans.

Cite

CITATION STYLE

APA

Barber, L. E., Bertrand, K. A., Petrick, J. L., Gerlovin, H., White, L. F., Adams-Campbell, L. L., … Palmer, J. R. (2021). Predicted Vitamin D Status and Colorectal Cancer Incidence in the Black Women’s Health Study. Cancer Epidemiology Biomarkers & Prevention, 30(12), 2334–2341. https://doi.org/10.1158/1055-9965.epi-21-0675

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free