Antioxidant Effect of Folic Acid and its Relation to Salivary Proteins and Oral Health

Abstract

‫الخالصة‬. ‫األهداف‬ : ‫الى‬ ‫الدراسة‬ ‫تِدف‬ ً‫لا‬ ‫ال‬ ‫التارّتٍي‬ ‫ّاًتااج‬ ‫اكسدادة‬ ‫هضاااا‬ ‫اًتاج‬ ‫على‬ ‫اللعاب‬ ‫قدرة‬ ‫على‬ ‫الفْلٍك‬ ‫بحوض‬ ‫الجِازي‬ ‫العالج‬ ‫تأثٍر‬ ‫تقٍٍن‬ ‫اسهي‬ ‫الوا‬ ‫اة‬ ‫ا‬ ‫الل‬ ‫ااب‬ ‫التِا‬ ‫اي‬ ‫ها‬ ‫ااًْى‬ ‫ٌعا‬ ‫ااٌي‬ ‫الا‬ ‫اى‬ ‫للورعا‬ ‫ان‬ ‫الفا‬ ‫احة‬ ‫فا‬ ‫ارا‬ ‫ا‬ ‫بوت‬ ‫اك‬ ‫كلا‬ ‫اة‬ ‫ّعالقا‬ ‫و‬ ‫مو‬ ‫ال‬ ‫وع‬ ‫و‬ ‫رائا‬ ‫وداو‬ ‫المو‬ ‫ا‬ ‫لا‬ ‫اا‬ ‫هرٌضا‬ ‫اٍي‬ ‫يربعا‬ ‫اٌٍب‬ ‫تيا‬ ‫ان‬ ‫تا‬ : ‫ى‬ :‫هجوْعتٍي‬-‫الوجوْعة‬ 1 (: 02 ‫الوجوْعاة‬)‫هراقتاة‬ ‫(هجوْعاة‬ ‫اّام‬ ‫يي‬ ‫ٌتلقاْا‬ ‫لان‬ ‫الواسهي‬ ‫ة‬ ‫الل‬ ‫بالتِاب‬ ‫هرعى‬) 0 (: 02 ‫بالتِااب‬ ‫هرعاى‬) ‫بجرعة‬ ‫بالٍْم‬ ً ‫ّاحدا‬ ً ‫قرفا‬ ‫تٌاّلْا‬)‫العالج‬ ‫(هجوْعة‬ ‫الوسهي‬ ‫ة‬ ‫الل‬ 1 ‫هدار‬ ‫على‬ ً ‫ٌْهٍا‬ ‫الفْلٍك‬ ‫حوض‬ ‫هي‬ ‫هلغن‬ 20 ‫الدراساة‬ ‫بداٌاة‬ ً‫ف‬ ً ‫ٌْها‬ ‫تان‬ ‫تان‬ ً‫التاال‬ ‫الٍاْم‬ ً‫فا‬ ‫الفان‬ ‫فاحة‬ ‫ار‬ ‫ّهت‬ ‫ة‬ ‫الل‬ ‫ر‬ ‫لوت‬ ‫االساش‬ ‫ًقطة‬ ‫لى‬ ‫للْفْل‬ ‫هتطْع‬ ‫ل‬ ‫ل‬ ‫ّالتلوٍع‬ ‫الدٌٍة‬ ‫لدا‬ ‫الت‬ ‫ازالة‬ ‫عولٍا‬ ‫تٌفٍا‬ ‫قٍااش‬ ‫بعد‬ ‫قٍاسِا‬ ‫تن‬ ‫ثن‬ ‫الوشارسٍي‬ ‫لجوٍع‬ ‫را‬ ‫الوت‬ ٍ‫ُا‬ 01 ‫بعد‬ ‫ثن‬ ً ‫ٌْها‬ 20 ‫هللٍلتار‬ ‫لوداة‬ ‫مواع‬ ‫تان‬ ‫زٌاارة‬ ‫سال‬ ً‫ّفا‬ ‫العاالج‬ ‫هي‬ ً ‫ٌْها‬ ‫اللعااب‬ ‫هاي‬ ً ْ‫الضا‬ ‫الطٍاب‬ ‫هقٍااش‬ ‫بْاساطة‬ ‫اهلاة‬ ‫ال‬ ‫اللعابٍاة‬ ‫ّالترّتٌٍا‬ ‫االسددة‬ ‫هضااا‬ ‫إلًتاج‬ ‫اللعابٍة‬ ‫القدرة‬ ‫لقٍاش‬ ‫ّكلك‬ ‫الوحفس‬ ‫غٍر‬ ‫النتوئ‬ ‫يظِار‬ : ‫علاى‬ ‫اللعابٍاة‬ ‫القادرة‬ ً‫فا‬ ‫ستٍار‬ ‫فارف‬ ‫ٌْماد‬ ‫ال‬ َ‫ّيًا‬ ‫االسدادة‬ ‫هضاااا‬ ‫اًتااج‬ ‫علاى‬ ‫اللعابٍة‬ ‫القدرة‬ ً‫ف‬ ‫ستٍر‬ ‫التالف‬ ‫ّمْا‬ ‫ج‬ ‫الٌتا‬ ‫الترّتٌٍاا‬ ‫اًتااج‬ ‫بعاد‬ ‫العاالج‬ ‫لوجوْعاة‬ ‫الفوٌْاة‬ ‫الٌفافاة‬ ‫ار‬ ‫ّهت‬ ‫اة‬ ‫الل‬ ‫ر‬ ‫هت‬ ً‫ف‬ ‫ستٍر‬ ‫فرف‬ ‫ٌْمد‬ ‫ال‬ ‫سالك‬ ‫اهلة‬ ‫ال‬ 6 ‫العاالج‬ ‫هاي‬ ‫يساابٍع‬ ‫االسوتنتئائ‬ ‫االساتددام‬ : ‫الترّت‬ ‫هداتٌْا‬ ‫هاي‬ ‫ٌّقلال‬ ‫االسدادة‬ ‫هضاااا‬ ‫اًتااج‬ ‫على‬ ‫اللعابٍة‬ ‫القدرة‬ ‫هي‬ ‫ٌحدي‬ ‫اى‬ ‫ي‬ ‫هو‬ ‫قيٍرة‬ ‫هدة‬ ‫لالل‬ ‫الفْلٍك‬ ‫لحوض‬ ‫علاى‬ ‫اللعابٍاة‬ ‫ٌٍاا‬ ‫ععٍب‬ ٍ ْ‫ًح‬ ABSTRACT Aims: To assay the effect of systemic treatment with folic acid on salivary total antioxidant capacity (TAC) and total protein (TP) in relation to oral health indices of patients with chronic gingivitis. Materials and Methods: Forty patients were classified into two groups :-Group 1: (n:20) chronic gingivitis patients, did not receive any medication (control group), Group 2: (n:20) chronic gingivitis patients (treatment group), received 1 mg\day oral tablet of folic acid for 42 days. At the beginning of study, scaling and polishing have been carried out for each volunteer to reach the base line for gingival index and oral hygiene index. In the next day, these indices were measured for all participants , then measured after 21 days then after 42 days from treatment. At all visits, five milliliters of unstimulated saliva were collected for measurement of salivary TAC and salivary TP by spectrophotometer. Results: the results revealed that there is a significant difference in salivary TAC of treatment group after 6 weeks, no significant difference in salivary TP during study period, no significant difference in gingival index and oral hygiene index between treatment and control group. Conclusions: sub-acute using of systemic folic acid in chronic gingivitis patients improves salivary TAC and decrease salivary TP slightly .