Responsive photonic alginate hydrogel particles for the quantitative detection of alkaline phosphatase

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Abstract

Alkaline phosphatase (ALP) is an important marker for many diseases, yet an efficient and reliable detection method is still lacking. Here, we present a novel photonic alginate hydrogel particle as an ALP sensor based on the competitive combination of an intermediary agent, the pyrophosphate ion (PPi), with a hydrogel crosslinker, which can trigger a phase-transition response from the hydrogel. This response can be converted into dual optical readouts, a fluorescence signal and a structural color signal. Quantitative determination of ALP was established based on this dual-indicator system with high accuracy and reliability. These features suggest potential ideal applications of responsive photonic hydrogel particles to detect ALP and other macromolecules.

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Wang, Y., Zhang, D., Zhang, H., Shang, L., & Zhao, Y. (2022). Responsive photonic alginate hydrogel particles for the quantitative detection of alkaline phosphatase. NPG Asia Materials, 14(1). https://doi.org/10.1038/s41427-022-00401-8

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